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KMID : 0032220130250040489
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Annals of Dermatology
2013 Volume.25 No. 4 p.489 ~ p.492
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New Onset Guttate Psoriasis Following Pandemic H1N1 Influenza Vaccination
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Shin Moon-Seub
Kim Soo-Jin
Kim Seong-Hyun
Kwak Yee-Gyoung
Park Hai-Jin
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Abstract
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Since the introduction of H1N1 influenza vaccine in the wake of the 2009 H1N1 pandemic, many serious and non-serious vaccine-related adverse events have been reported. The vaccination could induce pain, erythema, tenderness, and induration on injected areas. These symp-toms usually disappear in a few days after the vaccination. In this case, we observed a 26-year-old woman with multiple erythematous scaly macules scattered on the extremities and trunk. She was injected with an inactivated split-virus influenza A/H1N1 vaccine without adjuvant (Greenflu-S?, Green Corp.) on her left deltoid area 10 days earlier. The first lesion appeared on the injection site three days after the vaccination, and the following lesions spread to the trunk and extremities after a few days. Histopathological examina-tions showed neutrophilic collections within the parake-ratotic cornified layer, moderate acanthosis, diminished granular layer, elongation and edema of the dermal papillae, and dilated capillaries. The lesions were successfully treated with topical steroids and ultraviolet B phototherapy within three weeks, and there was no relapse for the following fourteen months. We assumed that pandemic vaccination was an important trigger for the onset of guttate psoriasis in this case. (Ann Dermatol 25(4) 489∼492, 2013)
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KEYWORD
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Psoriasis, Vaccination
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